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[BaseballLegend]

Thunderstrike i would use VGMDS but you cant make a baseball game on it, or any sports game

[felix]

You pretty much need to learn C/C++. Take a look at PAlib above. They have a pretty good tutorial.

[Perseid]

Felix is right. I don't know why people are talking about hex editors and whatnot. There's really no choice but to learn to program C/C++ using one of the NDS development libraries. That being said PAlib is very well-made and programming for the DS is easy compared to most other systems.